SCIENTIFIC AGENDA ASR reserves the right to substitute talks &/or speakers
1A. Plenary Overview: Karen Elkins, FDA - Correlates of protection for intracellular pathogens: Lessons from studying M. tuberculosis vaccination in genetically diverse mice
SATURDAY JULY 13 |
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Free Time / Optional Pre-Meeting Activities:
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| 12:00 - 5:30 PM | REGISTRATION DESK OPEN | Virginia Ballroom Lobby |
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12:00 - 3:00 PM |
Poster Set Up |
Virginia Ballroom D |
| 12:30 - 1:30 | Trainee Lunch & Mixer | Virginia Ballroom ABC |
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1:30 – 2:30 |
Trainee Career Development Session Moderator: Daniel Voth, Univ. of Arkansas Panelists: TBD |
Virginia Ballroom ABC |
| 2:30 - 3:00 | BREAK | |
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3:00 – 3:15 PM |
Welcome & Introductions Stacey Gilk, ASR President |
Virginia Ballroom ABC |
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3:15 – 5:00 PM |
Session 1: Epidemiology, Diagnostics, and Vaccine Development Session Chair: Kristin Mullins, Univ. of Maryland |
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| 3:15 PM | 1A. Plenary: Karen Elkins, FDA - Correlates of protection for intracellular pathogens: Lessons from studying M. tuberculosis vaccination in genetically diverse mice | |
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3:45 PM |
1B. Keynote: Roman Ganta, Univ. of Missouri - Molecular Genetic Tools Broadly Applicable in Ehrlichia and Anaplasma species to Define Essential Genes and Vaccine Development |
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4:15 PM |
1C. Johanna Salzer - National Surveillance for Human Ehrlichiosis caused by Ehrlichia ewingii— United States, 2013–2021 |
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4:30 PM |
1D. Perle Latre de Late - Inactivated whole cell bacterial antigen vaccine protects dogs from Rocky Mountain Spotted Fever caused by Rickettsia rickettsii independent of adjuvants used |
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4:45 PM |
1E. Karren Plain - Immunity in guinea pigs induced by a new Q-fever sub-unit vaccine based on the O-specific polysaccharide of virulent (phase 1) Coxiella burnetii |
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5:00 - 5:30 PM |
BREAK |
Virginia Foyer |
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5:30 – 6:30 PM |
Kelly Brayton, Washington State University |
Virginia Ballroom ABC |
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6:30 – 8:00 PM |
WELCOME RECEPTION |
Virginia Foyer & Lawn |
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Dinner on your own - View CWB Dining options |
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SUNDAY JULY 14 |
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| 7:30 - 8:30 AM |
BREAKFAST BUFFET |
Virginia Foyer |
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7:30 - 12:00 PM |
REGISTRATION DESK OPEN |
Virginia Foyer |
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8:30 – 10:15 AM |
Session 2: New Genetic Tools for Rickettsia Workshop Session Chair: Becky Lamason, MIT & Sam Perdue, NIH This workshop will feature recent recipients of the R61/R33 RFA “Genetic Tools for Understanding Rickettsial and Related Infections” and will enable facilitated discussions with attendees around the challenges, approaches, and current and future needs of the field.Panelists:
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Virginia Ballroom ABC |
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10:15 – 10:30 AM |
BREAK |
Virginia Foyer |
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10:30 – 12:15 PM |
Session 3: Coxiella Biology and Pathogenesis Session Chair: Carrie Mae Long, NIH |
Virginia Ballroom ABC |
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10:30 AM |
3A. Plenary Lecture: Shumin Tan, Tufts University -Illuminating the integration of Mycobacterium tuberculosis environmental cue response with its metabolism |
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11:00 AM |
3B. Keynote: Anders Omsland, Washington State University Coxiella: Metabolic Drivers of Virulence |
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11:30 AM |
3C. Nicole Ellis - Innovations in Multiplex CRISPRi Promote the Identification of Virulence Critical Genes in Legionella |
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11:45 AM |
3D. Het Adhvaryu - PERK-Dependent Mitochondrial Re-Programming of Human Alveolar Macrophages by Coxiella burnetii |
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12:00 PM |
3E. Zi Yang - Identification of a Coxiella burnetii porin required for intracellular replication |
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12:15 – 1:15 PM |
Lunch & ASR Power Hour (included) |
Virginia Ballroom DEF |
| 1:15 - 2:45 PM | Poster Session 1 | |
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Afternoon |
Free Time / Optional Group Excursion Dinner on your own - View CWB Dining options |
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MONDAY JULY 15 |
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| 7:30 - 8:30 AM |
BREAKFAST BUFFET |
Virginia Foyer |
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7:30 - 2:00 PM |
REGISTRATION DESK OPEN |
Virginia Foyer |
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8:30 – 10:15 AM |
Session 4: Cell Biology of Infection Session Chair: Yuejin Liang, Univ. of Texas Medical Branch |
Virginia Ballroom ABC |
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8:30 AM |
4A. Plenary Lecture: Isabelle Derre, Univ. of VA - How to make contact: A tale for three Chlamydia inclusion membrane proteins |
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9:00 AM |
4B. Keynote: Ted Hackstadt, NIH - The search for virulence determinants in spotted fever group rickettsia |
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9:30 AM |
4C. Thomas Siff - A conserved domain in multiple Orientia tsutsugamushi Ank effectors is critical for modulating NF-κB |
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9:45 AM |
4D. Rajendra Angara - CbEPF1’s molecular mimicry to manipulate host inter-organelle contact sites and host lipid droplet metabolism |
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10:00 AM |
4E. Sergio Lopez-Madrigal - Macromolecular tricks of a ubiquitous Anaplasmataceae |
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10:15 – 10:30 AM |
BREAK |
Virginia Foyer |
| 10:30 - 12:00 PM | Poster Session 2 | |
| 12:00 - 1:15 PM |
ASR Lunch (included) |
Virginia Ballroom DEF |
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1:15 - 3:00 PM |
Session 5: Host Immune Response Against Rickettsial Pathogens Session Chair: Erin van Schaik, Texas A&M University |
Virginia Ballroom ABC |
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1:15 PM |
5A: Plenary Lecture: Sunny Shin, Univ. of Pennsylvania |
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1:45 PM |
5B: Keynote: Joe Pedra, Univ. of Maryland - Immune-Epithelial Interactions During Tick-Borne Pathogen Transmission |
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2:15 PM |
5C. Oliver Voss - Pathogenic rickettsiae utilize the phosphatidylserine binding receptor, CD300f on macrophages for host invasion and pathogenesis |
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2:30 PM |
5D. Casey Gonzales - Orientia tsutsugamushi Karp vs. Gilliam Strains Elicit Differential Humoral Immune Responses in Mice |
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2:45 PM |
5E. Sean Riley - Genetic and Immunological Correlates of Susceptibility of Resistance to Rickettsia conorii Infection |
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3:00 – 3:30 PM |
BREAK |
Virginia Foyer |
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3:30 PM – 5:15 PM |
Session 6: Biology of Anaplasma and Ehrlichia Session Chair: Jason Park, Washington State University |
Virginia Ballroom ABC |
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3:30 PM |
6A: Plenary Lecture: Matt Lawrenz, Univ. of Louisville - Distinct Mechanisms of T3SS Recognition Control Leukotriene B4 Synthesis in Neutrophils and Macrophages |
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4:00 PM |
6B. Keynote: Nahed Ismail, Univ. of Illinois Chicago- Exploiting Cell Death Pathways in Ehrlichiosis for Novel Therapeutics |
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4:30 PM |
6C. Jason Park - Anaplasma phagocytophilum shifting gears in the tick vector |
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4:45 PM |
6D. Nur Saadet Cetin - Hepatocyte-Specific HMGB1-mediated inflammation and Cell Death Promotes Ehrlichia-induced Acute Liver Injury |
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5:00 PM |
6E. Andres Londono - Antimicrobial and innate immune coordinating functions of type I and II interferons in A. phagocytophilum infection |
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| 5:20 PM - 6:20 PM | ASR Business Meeting | Virginia Ballroom ABC |
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7:00 PM - 10:00 PM |
ASR GROUP DINNER at Shields Tavern (incl. reg. attendee & guests) |
Meet in lobby at 6:40 |
TUESDAY JULY 16 |
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| 7:30 - 8:30 AM |
BREAKFAST BUFFET |
Virginia Foyer |
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8:00 - 1:00 PM |
REGISTRATION DESK OPEN |
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8:30 – 10:15 AM |
Session 7: Vector Contribution to Rickettsial Pathogenesis Session Chair: Tais Saito, NIH |
Virginia Ballroom ABC |
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8:30 AM |
7A: Plenary Lecture: Monika Gulia-Nuss, Univ. of Nevada - Genome-editing to Combat Ticks and Tick-borne Disease |
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9:00 AM |
7B. Keynote: Susan Noh, USDA - From macro to micro: working across scales to understanding the tick-pathogen partnership |
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9:30 AM |
7C. Sujata Chaurdhari - Shaping the Shield: Exploring Tick Cuticle Remodeling |
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9:45 AM |
7D. Hanna Laukaitis - Functional and molecular characterization of hemocytes inIxodes scapularis |
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10:00 AM |
7E. Dana Shaw - APEX2 proximity proteomics in ticks reveals novel interactors in the UPR-IMD pathway circuitry |
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10:15 - 10:30 AM |
BREAK |
Ballroom I Lobby |
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10:30 – 12:15 PM |
Session 8: Tick-borne Rickettsia Session Chair: Hwan Kim, SUNY Stonybrook |
Virginia Ballroom ABC |
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10:30 AM |
8A. Plenary Lecture: Ken Fields, Univ. of Kentucky - Genetic manipulation of obligate intracellular bacteria—lessons learned from Chlamydia |
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11:00 AM |
8B. Keynote Speaker: Erin Goley, Johns Hopkins - Quantitative cell biology of Rickettsia parkeri |
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11:30 AM |
8C. Adam Nock - RoaM affects the transcription of several putative effectors inRickettsia rickettsii governing the transition to a cellular program of active spreading |
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11:45 AM |
8D. Hannah Margolis - Answering a century-old riddle: SFG Rickettsiae enter host nuclei through nuclear envelope protrusions using actin-based motility |
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12:00 PM |
8E. Luke Helminiak - Biological roles of a conserved rickettsial hemolysin, TlyC2, in Rickettsia-host-vector interactions |
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12:15 – 12:30 PM |
Closing Remarks |
Virginia Ballroom ABC |
Early Career Mentoring Session
ASR Lecture
The ASR Lecture is given by a distinguished investigator that has made significant contributions to the field of rickettsial diseases. The lecturer frames past public health observations and/or scientific discoveries in the context of current research. The ASR lecture also provides the community with challenges and opportunities in the realm of basic, clinical, and translational research.